منابع مشابه
Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats.
Obesity plays a pivotal role in the pathophysiology of metabolic and cardiovascular diseases. Resistance to insulin is commonly seen in metabolic disorders such as obesity and diabetes. Insulin-like growth factor-I (IGF-I) mimics insulin in many tissues and has been shown to enhance cardiac contractile function and growth. Because IGF-I resistance often accompanies resistance to insulin, we sou...
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Aldosterone is synthesized in extra-adrenal tissues, both blood vessels and brain. We undertook the present study to determine whether the rat heart produces aldosterone and to investigate the effects of adrenalectomy, ACE inhibition, and angiotensin II on aldosterone synthesis in the heart. To clarify the pathophysiological role of cardiac aldosterone in the hypertensive heart, we compared the...
متن کاملEffect of Genetically Modified Rice on Some Intestinal Microbial Flora in Rats
Background and purpose: Transgenic rice is a type of rice that its genetic sequence has been changed to improve its quantity and quality. Bt (Bacillus thuringiensis) transgenic rice expresses Cry1Ab protein and is named Tarom Molaii. There are no studies on the effect of this type of transgenic rice on gastrointestinal health in Iran, so, this study investigated the effect of Tarom Molaii tran...
متن کاملCentral pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.
Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-opiomelanocortin (rAAV-POMC) or control vector was delivered bilaterally into ...
متن کاملReduced graphene oxide: nanotoxicological profile in rats
BACKGROUND We have previously demonstrated that reduced graphene oxide (rGO) administered intravenously in rats was detected inside the hippocampus after downregulation of the tight and adherens junction proteins of the blood-brain barrier. While down-regulators of junctional proteins could be useful tools for drug delivery through the paracellular pathway, concerns over toxicity must be invest...
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ژورنال
عنوان ژورنال: Genetics
سال: 1948
ISSN: 1943-2631
DOI: 10.1093/genetics/33.6.565